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Figure 5 | Neural Development

Figure 5

From: Distinct roles of Hoxa2 and Krox20in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening

Figure 5

Naloxone treatment was effective on ventilation in Hoxa2-/- mice but did not increase survival. (a) Plethysmographic recordings before (control) and after naloxone (NLX) treatment in Hoxa2-/- animals. Note the frequency increase and the reduction of apneas. (b, c) Effects of the subcutanueous injection of NLX (1 mg/kg) at P0.5 upon mean ± standard error of the mean respiratory frequency calculated without apneic episodes in wild-type, Hoxa2+/-, Hoxa2-/- and Krox20-/- animals (b) or survival in the same genotypes (c). In (b, c) white bars indicate control values and black bars labeled NLX indicate values in the same animals one hour (b) (respiratory frequency) or 1.5 days (c) (survival) after NLX injection. Although NLX eliminates apneas (a) and increases respiratory frequency (by 31 + 11% in Hoxa2-/- and 51 ± 37 % in Krox20-/-) (b), it does not allow survival of Hoxa2-/- mutants (c).

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Neural Development

ISSN: 1749-8104