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Figure 2 | Neural Development

Figure 2

From: Distinct roles of Hoxa2 and Krox20in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening

Figure 2

Tidal volume of Hoxa2-/- and Krox20-/- mutants during the first postnatal days. Inset on the left: plethysmographic recordings of wild-type mice at different times after birth (P0) during the first postnatal day. Inspiration is upward and expiration is downward. Note the evolution of tidal volume (respiratory amplitude) and respiratory frequency during the first day. Calibration bars: abscissa, 1 s; ordinates, 10 μl. Graphs present the evolution of mean ± standard error of the mean. Tidal volume (VT) in wild-type mice (open squares, dotted line) and (a) Hoxa2-/- and (b) Krox20-/- mutants (black triangles, continuous line) during the first two days after birth. All mutants were dead shortly after P0.75, therefore explaining the lack of further data. Note that in wild-type and Krox20-/- animals, tidal volume rapidly increased during the first 12 hours of life whereas in Hoxa2-/- mice, tidal volume was already two-fold greater at P0.1. ***P < 0.001.

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Neural Development

ISSN: 1749-8104