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Figure 1 | Neural Development

Figure 1

From: Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning

Figure 1

Expression patterns of Sp5 in embryonic mouse forebrain and relationship with cortical hem and choroid plexus. (a-i) Sp5 expression relates to the cortical hem, a source of Wnts and Bmps. Shown are in situ hybridizations using DIG-labeled riboprobes for Sp5 on sagittal (a, d, g) or coronal (b, e, h) sections and Wnt2b (c, f, i) of mouse forebrain at E10.5 to E13.5. Sp5 expression is observed around the cortical hem and Cpe as being highest in medial and posterior parts of dorsal telencephalon (dTel; arrowhead), and quickly downregulated at E13.5. Unlike the expression of Sp8, Sp5 expression domains overlap those of Wnts throughout E10.5 to 13.5. Ctx, cortex; GE, ganglionic eminence; Hp, hippocampus. Scale bars: 0.5 mm

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Neural Development

ISSN: 1749-8104