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  1. Research article

    Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis

    How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar...

    Katrina C. McNeely, Timothy D. Cupp, Jessica Neville Little, Kerstin M. Janisch, Ayushma Shrestha and Noelle D. Dwyer

    Neural Development 2017 12:5

    Published on: 31 March 2017

  2. Research article

    Lacking of palladin leads to multiple cellular events changes which contribute to NTD

    The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi...

    Juan Tan, Xue-Jiao Chen, Chun-Ling Shen, Hong-Xin Zhang, Ling-Yun Tang, Shun-Yuan Lu, Wen-Ting Wu, Ying Kuang, Jian Fei and Zhu-Gang Wang

    Neural Development 2017 12:4

    Published on: 24 March 2017

  3. Research article

    The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development

    Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t...

    Burcu Erdogan, Garrett M. Cammarata, Eric J. Lee, Benjamin C. Pratt, Andrew F. Francl, Erin L. Rutherford and Laura Anne Lowery

    Neural Development 2017 12:3

    Published on: 15 February 2017

  4. Research Article

    Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain

    Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ...

    Michelle Ware, Houda Hamdi-Rozé, Julien Le Friec, Véronique David and Valérie Dupé

    Neural Development 2016 11:22

    Published on: 7 December 2016

  5. Research article

    Akirin2 is essential for the formation of the cerebral cortex

    The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel...

    Peter J. Bosch, Leah C. Fuller, Carolyn M. Sleeth and Joshua A. Weiner

    Neural Development 2016 11:21

    Published on: 21 November 2016

  6. Research article

    Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1

    Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro...

    Candace M. Marsters, Jessica M. Rosin, Hayley F. Thornton, Shaghayegh Aslanpour, Natasha Klenin, Grey Wilkinson, Carol Schuurmans, Quentin J. Pittman and Deborah M. Kurrasch

    Neural Development 2016 11:20

    Published on: 18 November 2016

  7. Short Report

    Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord

    Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during de...

    Harald J. Junge, Andrea R. Yung, Lisa V. Goodrich and Zhe Chen

    Neural Development 2016 11:19

    Published on: 26 October 2016

  8. Research article

    Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling

    Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo...

    Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song and Grant S. Mastick

    Neural Development 2016 11:18

    Published on: 22 October 2016

  9. Research article

    Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern

    The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...

    Emilie Legué, Jackie L. Gottshall, Edouard Jaumouillé, Alberto Roselló-Díez, Wei Shi, Luis Humberto Barraza, Senna Washington, Rachel L. Grant and Alexandra L. Joyner

    Neural Development 2016 11:17

    Published on: 8 September 2016

  10. Research article

    Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons

    Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...

    William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, José L. Juárez-Morales, Sarah de Jager, Olivier Armant, Jessica Legradi, Uwe Strähle, Brian A. Link and Katharine E. Lewis

    Neural Development 2016 11:16

    Published on: 23 August 2016

  11. Research article

    In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains

    In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a...

    Marie C. Reichert, Haley E. Brown and Timothy A. Evans

    Neural Development 2016 11:15

    Published on: 18 August 2016

  12. Research article

    Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

    Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...

    Torrey L. S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu, Kara G. Pratt, Hollis T. Cline and Carlos D. Aizenman

    Neural Development 2016 11:14

    Published on: 8 August 2016

  13. Research article

    Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells

    Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...

    Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin

    Neural Development 2016 11:13

    Published on: 28 July 2016

  14. Research article

    Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei

    Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ...

    Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa and Joshua G. Corbin

    Neural Development 2016 11:12

    Published on: 21 May 2016

  15. Short Report

    Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons

    The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat...

    Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, Shan Shan Li, Zhengdong Qu, Hannah Kate Vanyai, Hayley Daniella Cullen, John Michael Davis and Julian Ik-Tsen Heng

    Neural Development 2016 11:7

    Published on: 11 March 2016

  16. Reviewer acknowledgement

    Reviewer acknowledgement

    The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 10 (2015).

    Chris Q. Doe, William Harris, Kang Shen and Rachel Wong

    Neural Development 2016 11:6

    Published on: 8 March 2016

  17. Research article

    Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism

    For neurons to function correctly in neuronal circuitry they must utilize appropriate neurotransmitters. However, even though neurotransmitter specificity is one of the most important and defining properties o...

    José L. Juárez-Morales, Claus J. Schulte, Sofia A. Pezoa, Grace K. Vallejo, William C. Hilinski, Samantha J. England, Sarah de Jager and Katharine E. Lewis

    Neural Development 2016 11:5

    Published on: 19 February 2016

  18. Research article

    Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation

    Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympat...

    Gerard W. O’Keeffe, Humberto Gutierrez, Laura Howard, Christopher W. Laurie, Catarina Osorio, Núria Gavaldà, Sean L. Wyatt and Alun M. Davies

    Neural Development 2016 11:4

    Published on: 15 February 2016

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