Fig. 3From: Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficitsSpontaneous synaptic activity in tectal neurons is similar between control and FMRP KD tadpoles. a Example spontaneous EPSCs recorded at -60 mV in the presence of GABAA receptor blocker, picrotoxin. b Example spontaneous IPSCs recorded at +5 mV, the reversal potential for excitatory currents. c Frequency of sEPSCs. n = 28 for each group, PMW = 0.6784. d Amplitude of sEPSCs. n = 28 for each group, PMW =0.1069. e Frequency of sIPSCs. n = 18 control, n = 27 FMRP KD, PMW =0.1789. f Amplitude of sIPSCs. n = 18 control, n = 27 FMRP KD, PMW =0.5740. g Excitatory recurrent activity, defined as the presence of a barrage of activity at least 200 ms in duration with a change in holding current of at least 10pA. n = 28 for each group, PMW =0.3136. h Inhibitory recurrent activity, defined as the presence of a barrage of activity at least 200 ms in duration with a change in holding current of at least 10pA. n = 18 control, n = 27 FMRP KD, PMW =0.5101Back to article page