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Table 3 Functional annotation of mRNAs with altered stability based on neural-specific versus whole embryo measurements

From: Dynamic regulation of mRNA decay during neural development

mRNAs stabilized in the nervous system (neural/whole embryo half-life >1.5)

GO term

Definition

P value

FDR

Count

Fold enrichment

007409

Axonogenesis

2 × 10−3

.06

13

2.8

 

APC, CadN, trio, caps, fray, otk, daw

    

0003924

GTPase activity

2 × 10−3

.31

10

3.5

 

Rab21, Rab30, Ras64B, RabX1

    

0009312

Oligosaccharide biosynthesis

9 × 10−3

.15

4

9.2

 

mgat2, GalNAc-T1, pgant2, pgant5

    

0045196

Establishment of neuroblast polarity

.01

.16

3

18.7

 

par-6, baz, Lgl

    

0007269

Neurotransmitter secretion

.04

.56

6

2.6

 

CanB, Lgl, CASK, Dap160, cpx, rop

    

mRNAs destabilized in the nervous system (neural/whole embryo half-life <0.6)

GO term

Definition

P value

FDR

Count

Fold enrichment

0003735

Structural constituent of ribosome

5 × 10−17

5 × 10−15

26

9.2

 

RpL11, RpL30, RpL6, RpS16, RpS23

    

0000278

Mitotic cell cycle

4 × 10−8

4 × 10−5

30

3.2

 

dap, cycB3, ball, glu, eff, ncd, mts

    

0031497

Chromatin assembly

3 × 10−4

.02

7

7.5

 

H2B, H3, H3.3A/B, HP2, Df31, Set

    

0005839

Proteasome core complex

8 × 10−3

.07

5

6.0

 

Pros26, Prosα7, Prosβ2, Prosβ7

    

0006119

Oxidative phosphorylation

6 × 10−4

.03

12

3.5

 

ATPsynB, ATPsynD, mt:CoIII

    
  1. Gene ontology categories were identified using DAVID. Representative genes are listed for each category. FDR is the Benjamini-Hochberg false discovery rate.
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Neural Development

ISSN: 1749-8104