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Figure 5 | Neural Development

Figure 5

From: Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex

Figure 5

Bacurd2 interacts with its binding partners through distinct regions of the polypeptide. (A) Schematic representation of Bacurd2 polypeptide and its mutant variants used in our analysis. (B) Reciprocal co-immunoprecipitation assays show that Rnd2 interacts with an N-terminal Bacurd2 truncation mutant but is unable to bind the C-terminal truncation mutant Bacurd2(Δ221-316). (C) Cul3 binds Bacurd2(Δ221-316) but not the N-terminal truncation mutant Bacurd2(Δ1-109). (D) Mutations to I71/L72/I73 in the Bacurd2(3A) polypeptide sequence disrupt its interaction with Cul3. (E) Diagrammatic summary of the interactions between Bacurd2 and its interaction partners Rnd2 and Cul3.

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Neural Development

ISSN: 1749-8104