Figure 2

Model D _G1 is insensitive to perturbations in q _i and d _i . (A) Most (>90%) model realizations give plausible ventricular zone (VZ) output (gray bars). The distribution of 10,000 simulations of VZ output (where = 0.19 for all i) is plotted as a histogram. Simulation outputs follow a log-normal distribution. The solid vertical line indicates the geometric population mean, and dashed vertical lines indicate 1 and 2 standard deviations from the mean. (B) Three examples of points in 22-dimensional parameter space where plausible VZ output is observed. The q fractions are plotted along a dashed line and d fractions are plotted along a solid line. The upper panel is from a bin below the mean, the center panel is from the bin at the mean, and the lower panel is from a bin above the mean. CC, cell cycle.