Figure 2

Genetic interactions between Fak56 and integrin signaling pathway components during neuromuscular junction (NMJ) growth. (A-F) Images of NMJ 6/7 are shown as described for Figure 1C, D. Hypomorphic Fak56^{N 30/KG}mutants showed a normal morphology (A), but one allele of scb² (B), βν¹ (C) or LanA^9–32 (E) in Fak56^{N 30/KG}induced dramatic NMJ growth. Overelaborated NMJs in transheterozygotes βν^1/2 (D) and βν^1/+;LanA^9–32/+ (F) mutants are shown. (G) Quantification of NMJ 6/7 phenotypes for Fak56^{N 30/KG}, mew^1/+;Fak56^{N 30/KG}, if^{k 27e/+};Fak56^{N 30/KG}, scb^2/+ Fak56^{N 30/KG}, mys^1/+;Fak56^{N 30/KG}, βν^1/+Fak56^{N 30/KG}, Fak56^{N 30/KG};LanA^9–32/+, wb^{4Y 18/+}Fak56^{N 30/KG}, scb^2/+, βν^1/+, βν^1/2, LanA^9–32/216 and βν^1/+;LanA^9–32/+. Asterisks indicate significant difference by Student's t test (p < 0.05) and error bars represent the standard error of the mean (SEM).