Figure 7From: Bilateral enucleation alters gene expression and intraneocortical connections in the mouseAnalysis of ephrin A5 expression in two ROIs in the neocortex of control and enucleated mice. (A) Medial parietal cortex regions of interest overlaid on a representative coronal brain illustration. (B) Percent area fraction of cells expressing ephrin A5 within ROI1, located within the medial parietal cortex. A sharply increased percentage of transcript is observed in enucleated cases (31.46 ± 2.2%; df = 12; n = 7) when compared to control animals (0.49 ± 0.18%; df = 12; n = 7; P < 0.001; two-sample t-test). (C) Percent area fraction of cells expressing ephrin A5 within ROI2, located immediately lateral to ROI1. Percentage of ephrin A5 transcripts within the putative somatosensory cortex of enucleated animals (61.77 ± 1.18%; df = 12; n = 7) are not significantly different from controls (61.29 ± 1.00%; df = 12; n = 7; P = 0.47). CC: corpus callosum; CP: caudoputamen; CTX: cortex; df: degrees of freedom; LSr: lateral septal nucleus; ROI: region of interest.Back to article page